551
SMTP
551 User Not Local
The recipient is not local to this server and the server does not accept mail for forwarding. Unlike 251, this is a rejection — the server will not relay the message.
Quando você vê este código
When sending to a recipient that has moved or whose mailbox is hosted elsewhere, and this server refuses to forward the message to the new location.
Como corrigir
Check the server's response for a forwarding address and resend directly to that address. Update your contact records if the recipient has permanently moved to a new mail server.